Clone map viewer

Genome sequencing of cancers often reveals mosaics of different subclones present in the same tumour. While these are believed to arise according to the principles of somatic evolution, the exact spatial growth patterns and underlying mechanisms remain elusive. To address this we have developed a workflow that generates detailed quantitative maps of genetic subclone composition across whole tumour sections. The approach rests on whole genome sequencing, followed by highly multiplexed base specific in-situ sequencing (BaSISS), single cell resolved transcriptomics and dedicated algorithms to link these layers.

These maps provide the basis for studying clonal growth patterns, and each clone’s histological characteristics, microanatomy, and microenvironmental composition. Click on the vignettes below to explore datasets from two multifocal breast cancers and click here to learn how.

Spatial genomics maps the structure, nature and evolution of cancer clones
Artem Lomakin, Jessica Svedlund, Carina Strell, Milana Gataric, Artem Shmatko, Gleb Rukhovich, Jun Sung Park, Young Seok Ju, Stefan Dentro, Vitalii Kleshchevnikov, Vasyl Vaskivskyi, Tong Li, Omer Ali Bayraktar, Sarah Pinder, Andrea L. Richardson, Sandro Santagata, Peter J. Campbell, Hege Russnes, Moritz Gerstung, Mats Nilsson & Lucy R. Yates
Nature 611, 594–602 (2022) doi: 10.1038/s41586-022-05425-2